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Hypergenesis is a combo deck which uses a variety of cheap Cascade cards like Ardent Plea, Violent Outburst or Demonic Dread to power out the name-sake Hypergenesis. Using Simian Spirit Guide, this can be achieved as early as turn 1. When Hypergenesis resolves the player will put a variety of large creatures with destructive abilities onto the battlefield, such as Sundering Titan, Angel of Despair and/or Bogardan Hellkite. Straight up finisher creatures such as Progenitus or Akroma, Angel of Wrath are also popular to use. These large creatures should be capable of killing the opponent within one or two turns.

Evangelos Papatsarouchas entered the Top 8 of Pro Tour Austin 2009 with such a deck.

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